The Shimadzu Nexera LC-40 Series Preparative LC/SFC System (2022 Model) is a versatile, high-performance separation and purification platform designed for preparative liquid chromatography (LC) and supercritical fluid chromatography (SFC) applications. Combining Shimadzu’s advanced solvent delivery technology with automated sample handling, fraction collection, and photodiode array detection, this system provides an integrated solution for compound purification, isolation, and analytical research.
The system features an SFC-40P solvent delivery module and an LC-40P SF solvent delivery module, offering flexibility for SFC-based separations and solvent delivery configurations. The included LC-20AP preparative liquid chromatograph and LC-20AR liquid chromatograph support preparative and liquid chromatography workflows, while the CTO-40C column oven provides controlled column temperature conditions. The SPD-M40 photodiode array detector enables UV-visible spectral monitoring across multiple wavelengths, helping users identify and monitor separated compounds throughout the purification process.
For automated operation, the system includes an FRS-40 sampler and fraction collector, allowing collected fractions to be organized during purification runs. Additional components, including the DGU-403 degassing unit, HEX-40 solvent exchange module, FCV-20AH2 flow control valve, and CBM-40 communication bus module, support system operation and configuration. The system is operated through Shimadzu LabSolutions software, providing instrument control, data acquisition, chromatographic analysis, and management of analytical workflows.
This Nexera LC-40 system is well suited for pharmaceutical research and development, natural product isolation, chemical synthesis, compound purification, and other applications requiring flexible preparative LC and SFC capabilities. Its combination of liquid chromatography, supercritical fluid chromatography, automated fraction collection, and integrated software makes it a valuable solution for laboratories performing advanced separation and purification work.
System includes:
- CTO-40C column oven
- CBM-40 communication bus module
- SFC-40P solvent delivery module
- LC-40P SF solvent delivery module
- FCV-20AH2 flow control valve
- SPD-M40 photodiode array detector
- DGU-403 degassing unit
- HEX-40 solvent exchange module
- LC-20AR liquid chromatograph
- LC-20AP preparative liquid chromatograph
- FRS-40 sampler & fraction collector
- Labsolutions Data System

